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Effects of combined admistration of imatinib and sorafenib in a murine model of liver fibrosis. Molecules 2020

Molecules 2020, 25, 4310

In this work we have studied the effects of the PDGF inhibitor imatinib and the angiogenesis inhibitor sorafenib, administered alone or in combination, in reducing the progression of the fibrogenetic process in a pre-clinical model of liver damage induced in mice by repeated administration of Concanavalin A (ConA), resembling long-term autoimmune hepatitis. 


Effects of combined admistration of imatinib and sorafenib in a murine model of liver fibrosis. Molecules 2020
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Pesce A, Ciurleo R, Bramanti A, Armeli Iapichino E. C., Petralia M. C , Fagone P,  Bramanti P, Nicoletti F, Mangano K.